The genome of Onchocerca volvulus, agent of river blindness
نویسندگان
چکیده
منابع مشابه
Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness.
Onchocerciasis, also known as "river blindness", is a neglected tropical disease infecting millions of people mainly in Africa and the Middle East but also in South America and Central America. Disease infectivity initiates from the filarial parasitic nematode Onchocerca volvulus, which is transmitted by the blackfly vector Simulium sp. carrying infectious third-stage larvae. Ivermectin has con...
متن کاملCD4(+) depletion selectively inhibits eosinophil recruitment to the cornea and abrogates Onchocerca volvulus keratitis (River blindness).
Previous studies demonstrated that in the murine model of Onchocerca volvulus keratitis, neutrophils and eosinophils are recruited into the cornea in a biphasic manner in response to intrastromal injection. To determine if CD4(+) T cells regulate migration of neutrophils and eosinophils into the cornea, CD4(+) cells were depleted using monoclonal antibody GK1.5 before intrastromal injection of ...
متن کاملWolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88.
Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.
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Rick M. Maizels* Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, UK EH9 3JT. *e-mail: [email protected] Serine proteinases are ubiquitous enzymes involved in many physiologicial events in all taxonomic groups. Their activity, if uncontrolled, can be destructive to the cell or organism and must therefore be precisely regulated by endogenous...
متن کاملMolecular cloning of adenylate kinase from the human filarial parasite Onchocerca volvulus
Adenylate kinases (ADK) are ubiquitous enzymes that contribute to the homeostasis of adeninenucleotides in living cells. In this study, the cloning of a cDNA encoding an adenylate kinase from the filariaOnchocerca volvulus has been described. Using PCR technique, a 281 bp cDNA fragment encoding part ofan adenylate kinase was isolated from an O. volvulus cDNA library. Use of this fragment as a p...
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ژورنال
عنوان ژورنال: Nature Microbiology
سال: 2016
ISSN: 2058-5276
DOI: 10.1038/nmicrobiol.2016.216